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InVivoSIM anti-human CD20 (Ublituximab Biosimilar)

Clone	Catalog #	Category
Ublituximab	SIM0091

USD 235 - USD 8140

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-human CD20 (Ublituximab Biosimilar)

This non‑therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Ublituximab, making it ideal for research use. Ublituximab is a chimeric IgG1 monoclonal antibody that targets CD20, a transmembrane phosphoprotein expressed on pre‑B and mature B lymphocytes but not on plasma cells. CD20 is involved in B cell activation, proliferation, and calcium signaling. Ublituximab binds a unique epitope on CD20 and mediates potent B cell depletion primarily through antibody-dependent cellular cytotoxicity (ADCC). The original therapeutic antibody is glycoengineered for enhanced FcγRIIIa binding and effector function, though this research-grade biosimilar is not afucosylated. This Ublituximab biosimilar is ideal for exploring CD20 biology, B cell–mediated diseases, and mechanisms of B cell depletion in cancer and autoimmunity.

InVivoSIM anti-human CD20 (Ublituximab Biosimilar) Specifications

Isotype	Human IgG1, κ
Recommended Isotype Control(s)	RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Human CD20
Reported Applications	In vivo functional assays in vitro functional assays Flow cytometry ELISA
Formulation	pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.