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InVivoSIM anti-human CD3 x BCMA (Teclistamab Biosimilar)

Clone	Catalog #	Category
Teclistamab	SIM0067

USD 470 - USD 16280

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-human CD3 x BCMA (Teclistamab Biosimilar)

This non-therapeutic biosimilar antibody utilizes the same variable regions as the therapeutic antibody Teclistamab, making it ideal for research use. Teclistamab is a humanized IgG4 bispecific monoclonal antibody that targets both B-cell maturation antigen (BCMA) on malignant plasma cells and CD3ε on T cells. BCMA is predominantly expressed on plasma cells and plays a crucial role in their survival and proliferation. By simultaneously binding to BCMA and CD3, Teclistamab redirects T cells to recognize and eliminate BCMA-expressing multiple myeloma cells through T-cell activation and subsequent cytotoxicity. The Fc region of Teclistamab contains S228P/L234A/L235A mutations to minimize its immunological effector functions. This biosimilar antibody is a valuable tool for studying T-cell engagement, bispecific antibody mechanisms, and BCMA-targeted therapies.

InVivoSIM anti-human CD3 x BCMA (Teclistamab Biosimilar) Specifications

Isotype	Human IgG4, λ
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Human BCMA-Fc recombinant protein
Reported Applications	Functional assays Flow cytometry ELISA Immunohistochemistry
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.