About InVivoSIM anti-human CD3 x GPRC5D (Talquetamab Biosimilar) This non‑therapeutic bispecific biosimilar antibody uses the same variable regions as the therapeutic bispecific Talquetamab, making it ideal for research use. Talquetamab is a humanized IgG4 bispecific T‑cell engager (BiTE) that targets GPRC5D, a receptor highly expressed on multiple myeloma cells, and CD3ε on T cells. It redirects T cells to form a cytotoxic synapse with GPRC5D-positive tumor cells, triggering perforin- and granzyme-mediated apoptosis of malignant plasma cells. InVivoSIM anti-human CD3 x GPRC5D (Talquetamab Biosimilar) Specifications IsotypeHuman IgG4, κ Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer Reported ApplicationsFunctional assays Flow cytometry ELISA Immunohistochemistry FormulationPBS, pH 7.0 Contains no stabilizers or preservatives Endotoxin<0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay Aggregation<5% Determined by SEC Purity>95% Determined by SDS-PAGE Sterility0.2 μm filtration ProductionPurified from cell culture supernatant in an animal-free facility PurificationProtein A Molecular Weight150 kDa StorageThe antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
