{"id":"55","post_author":null,"post_date":null,"post_date_gmt":null,"post_content":null,"post_title":"InVivoSIM anti-human IgE (Omalizumab Biosimilar)","post_excerpt":"This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Omalizumab making it ideal for research use. This Omalizumab biosimilar reacts with free human IgE in blood and interstitial fluid and to membrane-bound IgE on the surface of IgE-expressing B cells. It does not bind to IgE that is already bound by the high affinity IgE receptor (Fc\u03b5RI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. It does not provoke histamine release from mast-cells sensitised by IgE. Omalizumab binds an epitope in proximity to the binding site of the Fc\u03b5RI.","post_status":"publish","comment_status":null,"ping_status":null,"post_password":null,"post_name":"invivosim-anti-human-ige-omalizumab-biosimilar-sim0016","to_ping":null,"pinged":null,"post_modified":null,"post_modified_gmt":null,"post_content_filtered":null,"post_parent":null,"guid":null,"menu_order":null,"post_type":null,"post_mime_type":null,"comment_count":null,"filter":null,"sku":"SIM0016","path":"\/product\/invivosim-anti-human-ige-omalizumab-biosimilar-sim0016\/","image":"https:\/\/pneuma.bioxcell.com\/Media\/Products\/bioxcell-sim0016-invivosim-anti-human-ige-omalizumab-biosimilar.png","brand_id":null,"brand_name":null,"brand_slug":null,"brand_description":null,"isotype":"Human IgG1, \u03ba","immunogen":"Human IgE","reported_applications":"<ul><li>IgE neutralization<\/li><li>Flow cytometry<\/li><li>ELISA<\/li><\/ul>","aggregation":"<5%\nDetermined by SEC","formulation":"PBS, pH 7.0\nContains no stabilizers or preservatives","murine_pathogen_tests":"Mouse Norovirus: Negative\nMouse Parvovirus: Negative\nMouse Minute Virus: Negative\nMouse Hepatitis Virus: Negative\nReovirus Screen: Negative\nLymphocytic Choriomeningitis virus: Negative\nLactate Dehydrogenase-Elevating Virus: Negative\nMouse Rotavirus: Negative\nTheiler's Murine Encephalomyelitis: Negative\nEctromelia\/Mousepox Virus: Negative\nHantavirus: Negative\nPolyoma Virus: Negative\nMouse Adenovirus: Negative\nSendai Virus: Negative\nMycoplasma Pulmonis: Negative\nPneumonia Virus of Mice: Negative\nMouse Cytomegalovirus: Negative\nK Virus: Negative","human_pathogen_tests":null,"toxicity_test_results":null,"endotoxin":"<ul><li>\u22640.5EU\/mg (\u22640.0005EU\/\u03bcg)<\/li><li>Determined by LAL gel clotting assay<\/li><\/ul>","purity":"<ul><li>\u226595%<\/li><li>Determined by SDS-PAGE<\/li><\/ul>","sterility":"0.2 \u03bcm filtration","production":null,"purification":"Protein A","composition":null,"volume":null,"concentration":null,"molecular_weight":"150 kDa","storage":"The antibody solution should be stored at the stock concentration at 4\u00b0C. Do not freeze.","rrid":"AB_2927532","recommended_isotype_control":"<a href=\"\/product\/\">RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme<\/a>","recommended_dilution_buffer":"<a href=\"\/product\/\">InVivoPure pH 7.0 Dilution Buffer<\/a>","clone":"Omalizumab","technical_data_sheet":"https:\/\/pneuma.bioxcell.com\/api\/v1\/products\/certificate-of-analysis\/SIM0016\/0\/0\/0?apikey=23D50188E6F74755AFFBF95BD41B140B","western_blot_image":null,"new_product_image":null,"product_references":null,"display_pubmed_logo":null,"modified":"2026-03-18 02:10:05","active":"Y"}

InVivoSIM anti-human IgE (Omalizumab Biosimilar)

Clone	Catalog #	Category
Omalizumab	SIM0016

USD 235 - USD 8140

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-human IgE (Omalizumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Omalizumab making it ideal for research use. This Omalizumab biosimilar reacts with free human IgE in blood and interstitial fluid and to membrane-bound IgE on the surface of IgE-expressing B cells. It does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. It does not provoke histamine release from mast-cells sensitised by IgE. Omalizumab binds an epitope in proximity to the binding site of the FcεRI.

InVivoSIM anti-human IgE (Omalizumab Biosimilar) Specifications

Isotype	Human IgG1, κ
Recommended Isotype Control(s)	RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Human IgE
Reported Applications	IgE neutralization Flow cytometry ELISA
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Purification	Protein A
RRID	AB_2927532
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.