{"id":"460","post_author":null,"post_date":null,"post_date_gmt":null,"post_content":null,"post_title":"InVivoSIM anti-human IL-12 p40 (Ustekinumab Biosimilar)","post_excerpt":"This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Ustekinumab making it ideal for research use. This Ustekinumab biosimilar reacts with human p40 also known as IL-12\u03b2. p40 is a 40 kDa subunit of IL-12 and IL-23. IL-12 is a heterodimeric cytokine composed of subunits IL-12\u03b1 p35 and IL-12\u03b2 p40. The p40 subunit of IL-12 also combines with p19, a protein that shows no biological activity by itself, to form IL-23. IL-12 is secreted by activated monocytes, macrophages, and dendritic cells while IL-23 is secreted by activated dendritic cells and epithelial cells. IL-12 plays roles in T lymphocyte differentiation, IFN\u03b3 production, and NK cell cytotoxicity. The C17.8 antibody has been shown to neutralize both IL-12 and IL-23 bioactivity. Ustekinumab is used for the treatment of Crohn\u2019s disease, plaque psoriasis, and psoriatic arthritis.","post_status":"publish","comment_status":null,"ping_status":null,"post_password":null,"post_name":"invivosim-anti-human-il-12-p40-ustekinumab-biosimilar-sim0020","to_ping":null,"pinged":null,"post_modified":null,"post_modified_gmt":null,"post_content_filtered":null,"post_parent":null,"guid":null,"menu_order":null,"post_type":null,"post_mime_type":null,"comment_count":null,"filter":null,"sku":"SIM0020","path":"\/product\/invivosim-anti-human-il-12-p40-ustekinumab-biosimilar-sim0020\/","image":"https:\/\/pneuma.bioxcell.com\/Media\/Products\/bioxcell-sim0020-invivosim-anti-human-il-12-p40-ustekinumab-biosimilar.png","brand_id":null,"brand_name":null,"brand_slug":null,"brand_description":null,"isotype":"Human IgG1, \u03ba","immunogen":"Human IL-12 p40","reported_applications":"Functional assays\n","aggregation":"<5%\nDetermined by SEC","formulation":"PBS, pH 7.0\nContains no stabilizers or preservatives","murine_pathogen_tests":"<ul><li>Mouse Norovirus: Negative<\/li><li>Mouse Parvovirus: Negative<\/li><li>Mouse Minute Virus: Negative<\/li><li>Mouse Hepatitis Virus: Negative<\/li><li>Reovirus Screen: Negative<\/li><li>Lymphocytic Choriomeningitis virus: Negative<\/li><li>Lactate Dehydrogenase-Elevating Virus: Negative<\/li><li>Mouse Rotavirus: Negative<\/li><li>Theiler's Murine Encephalomyelitis: Negative<\/li><li>Ectromelia\/Mousepox Virus: Negative<\/li><li>Hantavirus: Negative<\/li><li>Polyoma Virus: Negative<\/li><li>Mouse Adenovirus: Negative<\/li><li>Sendai Virus: Negative<\/li><li>Mycoplasma Pulmonis: Negative<\/li><li>Pneumonia Virus of Mice: Negative<\/li><li>Mouse Cytomegalovirus: Negative<\/li><li>K Virus: Negative<\/li><\/ul>","human_pathogen_tests":"","toxicity_test_results":null,"endotoxin":"<ul><li>\u22640.5EU\/mg (\u22640.0005EU\/\u03bcg)<\/li><li>Determined by LAL gel clotting assay<\/li><\/ul>","purity":"<ul><li>\u226595%<\/li><li>Determined by SDS-PAGE<\/li><\/ul>","sterility":"0.2 \u03bcm filtration","production":"Purified from cell culture supernatant in an animal-free facility.","purification":"Protein A","composition":null,"volume":null,"concentration":null,"molecular_weight":"150 kDa","storage":"The antibody solution should be stored at the stock concentration at 4\u00b0C. Do not freeze.","rrid":"","recommended_isotype_control":"<a href=\"\/product\/\">RecombiMAb human IgG1 (D265A) isotype control, anti-hen egg lysozyme<\/a>","recommended_dilution_buffer":"<a href=\"\/product\/\">InVivoPure pH 7.0 Dilution Buffer<\/a>","clone":"Ustekinumab","technical_data_sheet":"https:\/\/pneuma.bioxcell.com\/api\/v1\/products\/certificate-of-analysis\/SIM0020\/0\/0\/0?apikey=23D50188E6F74755AFFBF95BD41B140B","western_blot_image":null,"new_product_image":null,"product_references":null,"display_pubmed_logo":null,"modified":"2026-03-18 02:10:05","active":"Y"}

InVivoSIM anti-human IL-12 p40 (Ustekinumab Biosimilar)

Clone	Catalog #	Category
Ustekinumab	SIM0020

USD 235 - USD 8140

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-human IL-12 p40 (Ustekinumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Ustekinumab making it ideal for research use. This Ustekinumab biosimilar reacts with human p40 also known as IL-12β. p40 is a 40 kDa subunit of IL-12 and IL-23. IL-12 is a heterodimeric cytokine composed of subunits IL-12α p35 and IL-12β p40. The p40 subunit of IL-12 also combines with p19, a protein that shows no biological activity by itself, to form IL-23. IL-12 is secreted by activated monocytes, macrophages, and dendritic cells while IL-23 is secreted by activated dendritic cells and epithelial cells. IL-12 plays roles in T lymphocyte differentiation, IFNγ production, and NK cell cytotoxicity. The C17.8 antibody has been shown to neutralize both IL-12 and IL-23 bioactivity. Ustekinumab is used for the treatment of Crohn’s disease, plaque psoriasis, and psoriatic arthritis.

InVivoSIM anti-human IL-12 p40 (Ustekinumab Biosimilar) Specifications

Isotype	Human IgG1, κ
Recommended Isotype Control(s)	RecombiMAb human IgG1 (D265A) isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Human IL-12 p40
Reported Applications	Functional assays
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Production	Purified from cell culture supernatant in an animal-free facility.
Purification	Protein A
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.