{"id":"849","post_author":null,"post_date":null,"post_date_gmt":null,"post_content":null,"post_title":"InVivoSIM anti-human IL-31RA (Nemolizumab Biosimilar)","post_excerpt":"This non\u2011therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Nemolizumab making it ideal for research use. Nemolizumab is a humanized IgG2 monoclonal antibody that specifically targets the interleukin-31 receptor alpha (IL-31RA). IL\u201131RA is primarily expressed on keratinocytes, dorsal root ganglion (DRG) neurons, monocytes, macrophages, and dendritic cells, where it mediates the biological effects of IL\u201131, a cytokine known for driving pruritus, inflammation, and epithelial barrier dysfunction. By binding to IL-31RA, it blocks the signaling of interleukin-31 (IL\u201131)\u2014a neuroimmune cytokine that drives itch (pruritus), skin inflammation, barrier dysfunction, and fibrosis\u2014thereby interrupting the pathogenic itch\u2013scratch cycle seen in skin disorders like atopic dermatitis (AD) and prurigo nodularis (PN)\u202f. Nemolizumab has been shown to provide rapid and sustained relief of pruritus in clinical trials involving AD and PN by modulating neuroimmune pathways, improving skin integrity, and reducing inflammation\u202f. This Nemolizumab biosimilar  is well suited for studying IL\u201131 signaling, neuroimmune interactions in itch, barrier function, and the development of anti-pruritic therapeutics.","post_status":"publish","comment_status":null,"ping_status":null,"post_password":null,"post_name":"invivosim-anti-human-il-31ra-nemolizumab-biosimilar-sim0078","to_ping":null,"pinged":null,"post_modified":null,"post_modified_gmt":null,"post_content_filtered":null,"post_parent":null,"guid":null,"menu_order":null,"post_type":null,"post_mime_type":null,"comment_count":null,"filter":null,"sku":"SIM0078","path":"\/product\/invivosim-anti-human-il-31ra-nemolizumab-biosimilar-sim0078\/","image":"https:\/\/pneuma.bioxcell.com\/Media\/Products\/bioxcell-sim0078-invivosim-anti-human-il-31ra-nemolizumab-biosimilar.png","brand_id":null,"brand_name":null,"brand_slug":null,"brand_description":null,"isotype":"Human IgG2, \u03ba","immunogen":"Human IL-31RA","reported_applications":"in vivo functional assays\nin vitro functional assays\nFlow cytometry\nELISA","aggregation":"<5%\nDetermined by SEC","formulation":"PBS, pH 7.0\nContains no stabilizers or preservatives","murine_pathogen_tests":"Mouse Norovirus: Negative\nMouse Parvovirus: Negative\nMouse Minute Virus: Negative\nMouse Hepatitis Virus: Negative\nReovirus Screen: Negative\nLymphocytic Choriomeningitis virus: Negative\nLactate Dehydrogenase-Elevating Virus: Negative\nMouse Rotavirus: Negative\nTheiler's Murine Encephalomyelitis: Negative\nEctromelia\/Mousepox Virus: Negative\nHantavirus: Negative\nPolyoma Virus: Negative\nMouse Adenovirus: Negative\nSendai Virus: Negative\nMycoplasma Pulmonis: Negative\nPneumonia Virus of Mice: Negative\nMouse Cytomegalovirus: Negative\nK Virus: Negative","human_pathogen_tests":"","toxicity_test_results":null,"endotoxin":"<ul><li>\u22640.5EU\/mg (\u22640.0005EU\/\u03bcg)<\/li><li>Determined by LAL gel clotting assay<\/li><\/ul>","purity":"<ul><li>\u226595%<\/li><li>Determined by SDS-PAGE<\/li><\/ul>","sterility":"0.2 \u03bcm filtration","production":"Purified from cell culture supernatant in an animal-free facility","purification":"Protein A","composition":null,"volume":null,"concentration":null,"molecular_weight":"150 kDa","storage":"The antibody solution should be stored at the stock concentration at 4\u00b0C. Do not freeze.","rrid":"","recommended_isotype_control":"<a href=\"\/product\/\">RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme<\/a>","recommended_dilution_buffer":"<a href=\"\/product\/\">InVivoPure pH 7.0 Dilution Buffer<\/a>","clone":"Nemolizumab","technical_data_sheet":"https:\/\/pneuma.bioxcell.com\/api\/v1\/products\/certificate-of-analysis\/SIM0078\/0\/0\/0?apikey=23D50188E6F74755AFFBF95BD41B140B","western_blot_image":null,"new_product_image":null,"product_references":null,"display_pubmed_logo":null,"modified":"2026-03-18 02:10:05","active":"Y"}

InVivoSIM anti-human IL-31RA (Nemolizumab Biosimilar)

Clone	Catalog #	Category
Nemolizumab	SIM0078

USD 235 - USD 8140

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-human IL-31RA (Nemolizumab Biosimilar)

This non‑therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Nemolizumab making it ideal for research use. Nemolizumab is a humanized IgG2 monoclonal antibody that specifically targets the interleukin-31 receptor alpha (IL-31RA). IL‑31RA is primarily expressed on keratinocytes, dorsal root ganglion (DRG) neurons, monocytes, macrophages, and dendritic cells, where it mediates the biological effects of IL‑31, a cytokine known for driving pruritus, inflammation, and epithelial barrier dysfunction. By binding to IL-31RA, it blocks the signaling of interleukin-31 (IL‑31)—a neuroimmune cytokine that drives itch (pruritus), skin inflammation, barrier dysfunction, and fibrosis—thereby interrupting the pathogenic itch–scratch cycle seen in skin disorders like atopic dermatitis (AD) and prurigo nodularis (PN) . Nemolizumab has been shown to provide rapid and sustained relief of pruritus in clinical trials involving AD and PN by modulating neuroimmune pathways, improving skin integrity, and reducing inflammation . This Nemolizumab biosimilar is well suited for studying IL‑31 signaling, neuroimmune interactions in itch, barrier function, and the development of anti-pruritic therapeutics.

InVivoSIM anti-human IL-31RA (Nemolizumab Biosimilar) Specifications

Isotype	Human IgG2, κ
Recommended Isotype Control(s)	RecombiMAb human IgG2 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Human IL-31RA
Reported Applications	in vivo functional assays in vitro functional assays Flow cytometry ELISA
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.