{"id":"499","post_author":null,"post_date":null,"post_date_gmt":null,"post_content":null,"post_title":"InVivoSIM anti-human integrin \u03b14\u03b27 (LPAM-1) (Vedolizumab Biosimilar)","post_excerpt":"This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Vedolizumab making it ideal for research use. This Vedolizumab biosimilar reacts with integrin \u03b14\u03b27. The 130 kDa integrin \u03b27 chain associates with the 150 kDa integrin \u03b14 (CD49d) chain to form LPAM-1, a member of the Ig superfamily. LPAM-1 is expressed by peripheral lymphocytes, small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds VCAM-1 (CD106), MAdCAM-1, and fibronectin and facilitates lymphocyte adhesion and migration to the intestine and associated lymphoid tissues. Vedolizumab binds specifically to the \u03b14\u03b27 integrin heterodimer, but not to the functionally distinct \u03b14\u03b21 or \u03b1E\u03b27 integrin heterodimers, thereby inhibiting the binding of \u03b14\u03b27-expressing cells to MAdCAM-1 and fibronectin, but not to VCAM-1.","post_status":"publish","comment_status":null,"ping_status":null,"post_password":null,"post_name":"invivosim-anti-human-integrin-47-lpam-1-vedolizumab-biosimilar-sim0024","to_ping":null,"pinged":null,"post_modified":null,"post_modified_gmt":null,"post_content_filtered":null,"post_parent":null,"guid":null,"menu_order":null,"post_type":null,"post_mime_type":null,"comment_count":null,"filter":null,"sku":"SIM0024","path":"\/product\/invivosim-anti-human-integrin-47-lpam-1-vedolizumab-biosimilar-sim0024\/","image":"https:\/\/pneuma.bioxcell.com\/Media\/Products\/bioxcell-sim0024-invivosim-anti-human-integrin-alpha4beta7-lpam-1-vedolizumab-biosimilar.png","brand_id":null,"brand_name":null,"brand_slug":null,"brand_description":null,"isotype":"Human IgG1, \u03ba","immunogen":"Human integrin \u03b14\u03b27 (LPAM-1)","reported_applications":"Functional assays\nELISA\nWestern blot\n","aggregation":"<5%\nDetermined by SEC","formulation":"PBS, pH 7.0\nContains no stabilizers or preservatives","murine_pathogen_tests":"Mouse Norovirus: Negative\nMouse Parvovirus: Negative\nMouse Minute Virus: Negative\nMouse Hepatitis Virus: Negative\nReovirus Screen: Negative\nLymphocytic Choriomeningitis virus: Negative\nLactate Dehydrogenase-Elevating Virus: Negative\nMouse Rotavirus: Negative\nTheiler's Murine Encephalomyelitis: Negative\nEctromelia\/Mousepox Virus: Negative\nHantavirus: Negative\nPolyoma Virus: Negative\nMouse Adenovirus: Negative\nSendai Virus: Negative\nMycoplasma Pulmonis: Negative\nPneumonia Virus of Mice: Negative\nMouse Cytomegalovirus: Negative\nK Virus: Negative\n","human_pathogen_tests":"","toxicity_test_results":null,"endotoxin":"<ul><li>\u22640.5EU\/mg (\u22640.0005EU\/\u03bcg)<\/li><li>Determined by LAL gel clotting assay<\/li><\/ul>","purity":"<ul><li>\u226595%<\/li><li>Determined by SDS-PAGE<\/li><\/ul>","sterility":"0.2 \u03bcm filtration","production":"Purified from cell culture supernatant in an animal-free facility","purification":"Protein A","composition":null,"volume":null,"concentration":null,"molecular_weight":"150 kDa","storage":"The antibody solution should be stored at the stock concentration at 4\u00b0C. Do not freeze.","rrid":"","recommended_isotype_control":"<a href=\"\/product\/\">RecombiMAb human IgG1 (LALA-PG) isotype control, anti-respiratory syncytial virus <\/a>","recommended_dilution_buffer":"<a href=\"\/product\/\">InVivoPure pH 7.0 Dilution Buffer<\/a>","clone":"Vedolizumab","technical_data_sheet":"https:\/\/pneuma.bioxcell.com\/api\/v1\/products\/certificate-of-analysis\/SIM0024\/0\/0\/0?apikey=23D50188E6F74755AFFBF95BD41B140B","western_blot_image":null,"new_product_image":null,"product_references":null,"display_pubmed_logo":null,"modified":"2026-03-20 02:10:06","active":"Y"}

InVivoSIM anti-human integrin α4β7 (LPAM-1) (Vedolizumab Biosimilar)

Clone	Catalog #	Category
Vedolizumab	SIM0024

USD 235 - USD 8140

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-human integrin α4β7 (LPAM-1) (Vedolizumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Vedolizumab making it ideal for research use. This Vedolizumab biosimilar reacts with integrin α4β7. The 130 kDa integrin β7 chain associates with the 150 kDa integrin α4 (CD49d) chain to form LPAM-1, a member of the Ig superfamily. LPAM-1 is expressed by peripheral lymphocytes, small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds VCAM-1 (CD106), MAdCAM-1, and fibronectin and facilitates lymphocyte adhesion and migration to the intestine and associated lymphoid tissues. Vedolizumab binds specifically to the α4β7 integrin heterodimer, but not to the functionally distinct α4β1 or αEβ7 integrin heterodimers, thereby inhibiting the binding of α4β7-expressing cells to MAdCAM-1 and fibronectin, but not to VCAM-1.

InVivoSIM anti-human integrin α4β7 (LPAM-1) (Vedolizumab Biosimilar) Specifications

Isotype	Human IgG1, κ
Recommended Isotype Control(s)	RecombiMAb human IgG1 (LALA-PG) isotype control, anti-respiratory syncytial virus
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Human integrin α4β7 (LPAM-1)
Reported Applications	Functional assays ELISA Western blot
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.