{"id":"536","post_author":null,"post_date":null,"post_date_gmt":null,"post_content":null,"post_title":"InVivoSIM anti-human PD-L1 (Durvalumab Biosimilar)","post_excerpt":"This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Durvalumab making it ideal for research use. This Durvalumab biosimilar reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFN\u03b3 stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis. Durvalumab blocks the interaction of PD-L1 with PD-1 and CD80.","post_status":"publish","comment_status":null,"ping_status":null,"post_password":null,"post_name":"invivosim-anti-human-pd-l1-durvalumab-biosimilar-sim0027","to_ping":null,"pinged":null,"post_modified":null,"post_modified_gmt":null,"post_content_filtered":null,"post_parent":null,"guid":null,"menu_order":null,"post_type":null,"post_mime_type":null,"comment_count":null,"filter":null,"sku":"SIM0027","path":"\/product\/invivosim-anti-human-pd-l1-durvalumab-biosimilar-sim0027\/","image":"https:\/\/pneuma.bioxcell.com\/Media\/Products\/bioxcell-sim0027-invivosim-anti-human-pd-l1-durvalumab-biosimilar.png","brand_id":null,"brand_name":null,"brand_slug":null,"brand_description":null,"isotype":"Human IgG1, \u03ba","immunogen":"Human PD-L1\/B7-H1","reported_applications":"ELISA\nFlow Cytometry\nWestern Blot\nFunctional assays","aggregation":"<5%\nDetermined by SEC","formulation":"PBS, pH 7.0\nContains no stabilizers or preservatives","murine_pathogen_tests":"Mouse Norovirus: Negative\nMouse Parvovirus: Negative\nMouse Minute Virus: Negative\nMouse Hepatitis Virus: Negative\nReovirus Screen: Negative\nLymphocytic Choriomeningitis virus: Negative\nLactate Dehydrogenase-Elevating Virus: Negative\nMouse Rotavirus: Negative\nTheiler's Murine Encephalomyelitis: Negative\nEctromelia\/Mousepox Virus: Negative\nHantavirus: Negative\nPolyoma Virus: Negative\nMouse Adenovirus: Negative\nSendai Virus: Negative\nMycoplasma Pulmonis: Negative\nPneumonia Virus of Mice: Negative\nMouse Cytomegalovirus: Negative\nK Virus: Negative","human_pathogen_tests":"","toxicity_test_results":null,"endotoxin":"<ul><li>\u22640.5EU\/mg (\u22640.0005EU\/\u03bcg)<\/li><li>Determined by LAL gel clotting assay<\/li><\/ul>","purity":"<ul><li>\u226595%<\/li><li>Determined by SDS-PAGE<\/li><\/ul>","sterility":"0.2 \u03bcm filtration","production":"Purified from cell culture supernatant in an animal-free facility","purification":"Protein A","composition":null,"volume":null,"concentration":null,"molecular_weight":"150 kDa","storage":"The antibody solution should be stored at the stock concentration at 4\u00b0C. Do not freeze.","rrid":"","recommended_isotype_control":"<a href=\"\/product\/\">RecombiMAb human IgG1 (LALA-PG) isotype control, anti-hen egg lysozyme<\/a>","recommended_dilution_buffer":"<a href=\"\/product\/\">InVivoPure pH 7.0 Dilution Buffer<\/a>","clone":"Durvalumab","technical_data_sheet":"https:\/\/pneuma.bioxcell.com\/api\/v1\/products\/certificate-of-analysis\/SIM0027\/0\/0\/0?apikey=23D50188E6F74755AFFBF95BD41B140B","western_blot_image":null,"new_product_image":null,"product_references":null,"display_pubmed_logo":null,"modified":"2026-03-18 02:10:05","active":"Y"}

InVivoSIM anti-human PD-L1 (Durvalumab Biosimilar)

Clone	Catalog #	Category
Durvalumab	SIM0027

USD 235 - USD 8140

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-human PD-L1 (Durvalumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Durvalumab making it ideal for research use. This Durvalumab biosimilar reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis. Durvalumab blocks the interaction of PD-L1 with PD-1 and CD80.

InVivoSIM anti-human PD-L1 (Durvalumab Biosimilar) Specifications

Isotype	Human IgG1, κ
Recommended Isotype Control(s)	RecombiMAb human IgG1 (LALA-PG) isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Human PD-L1/B7-H1
Reported Applications	ELISA Flow Cytometry Western Blot Functional assays
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.