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InVivoSIM anti-human VEGFR-2 (Ramucirumab Biosimilar)

Clone	Catalog #	Category
Ramucirumab	SIM0012

USD 235 - USD 8140

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-human VEGFR-2 (Ramucirumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Ramucirumab making it ideal for research use. This Ramucirumab biosimilar reacts with human VEGFR-2 (vascular endothelial growth factor receptor 2) also known as CD309, KDR, and Flk-1. VEGFR-2 is a member of the tyrosine protein kinase family. Upon binding to its ligand VEGF, VEGFR-2 pays key roles in vascular development and permeability. VEGFR-2 is expressed on endothelial cells at high levels in adult heart, lung, kidney, brain, and skeletal muscle as well as other tissues at lower levels. Ramucirumab binds to the extracellular domain of VEGFR-2 and blocks the binding of VEGFR ligands VEGF-A, VEGF-C and VEGF-D leading to inhibition of VEGF-mediated tumor angiogenesis.

InVivoSIM anti-human VEGFR-2 (Ramucirumab Biosimilar) Specifications

Isotype	Human IgG1
Recommended Isotype Control(s)	RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Human VEGFR2
Reported Applications	Functional assays Immunohistochemistry Flow cytometry
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
RRID	AB_2894733
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.