{"id":"871","post_author":null,"post_date":null,"post_date_gmt":null,"post_content":null,"post_title":"InVivoSIM anti-respiratory syncytial virus (RSV) F protein (Nirsevimab Biosimilar)","post_excerpt":"This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Nirsevimab, making it ideal for research use. Nirsevimab is a human IgG1 monoclonal antibody that targets the fusion (F) glycoprotein of respiratory syncytial virus (RSV), a highly contagious virus that causes serious respiratory infections, particularly in infants and older adults. The RSV F protein plays a critical role in viral entry by mediating the fusion of viral and host cell membranes, making it a key target for neutralization. Nirsevimab binds to a highly conserved epitope on the prefusion conformation of the RSV F protein, thereby preventing the conformational changes required for membrane fusion and subsequent infection. Unlike palivizumab, which binds both pre- and postfusion forms, Nirsevimab is specific to the prefusion form, enabling higher potency and prolonged protection. This Nirsevimab biosimilar is ideal for studying RSV entry mechanisms, neutralizing antibody responses, and RSV vaccine or therapeutic development.","post_status":"publish","comment_status":null,"ping_status":null,"post_password":null,"post_name":"invivosim-anti-respiratory-syncytial-virus-rsv-f-protein-nirsevimab-biosimilar-sim0088","to_ping":null,"pinged":null,"post_modified":null,"post_modified_gmt":null,"post_content_filtered":null,"post_parent":null,"guid":null,"menu_order":null,"post_type":null,"post_mime_type":null,"comment_count":null,"filter":null,"sku":"SIM0088","path":"\/product\/invivosim-anti-respiratory-syncytial-virus-rsv-f-protein-nirsevimab-biosimilar-si","image":"https:\/\/pneuma.bioxcell.com\/Media\/Products\/bioxcell-sim0088-invivosim-anti-respiratory-syncytial-virus-rsv-f-protein-nirsevimab-biosimilar.png","brand_id":null,"brand_name":null,"brand_slug":null,"brand_description":null,"isotype":"Human IgG1, \u03ba","immunogen":"RSV F protein","reported_applications":"In vivo functional assays\nin vitro functional assays\nFlow cytometry\nELISA","aggregation":"<5%\nDetermined by SEC","formulation":"pH 7.0\nContains no stabilizers or preservatives","murine_pathogen_tests":"Mouse Norovirus: Negative\nMouse Parvovirus: Negative\nMouse Minute Virus: Negative\nMouse Hepatitis Virus: Negative\nReovirus Screen: Negative\nLymphocytic Choriomeningitis virus: Negative\nLactate Dehydrogenase-Elevating Virus: Negative\nMouse Rotavirus: Negative\nTheiler's Murine Encephalomyelitis: Negative\nEctromelia\/Mousepox Virus: Negative\nHantavirus: Negative\nPolyoma Virus: Negative\nMouse Adenovirus: Negative\nSendai Virus: Negative\nMycoplasma Pulmonis: Negative\nPneumonia Virus of Mice: Negative\nMouse Cytomegalovirus: Negative\nK Virus: Negative","human_pathogen_tests":"","toxicity_test_results":null,"endotoxin":"<ul><li>\u22640.5EU\/mg (\u22640.0005EU\/\u03bcg)<\/li><li>Determined by LAL gel clotting assay<\/li><\/ul>","purity":"<ul><li>\u226595%<\/li><li>Determined by SDS-PAGE<\/li><\/ul>","sterility":"0.2 \u03bcm filtration","production":"Purified from cell culture supernatant in an animal-free facility","purification":"Protein A","composition":null,"volume":null,"concentration":null,"molecular_weight":"150 kDa","storage":"The antibody solution should be stored at the stock concentration at 4\u00b0C. Do not freeze.","rrid":"","recommended_isotype_control":"<a href=\"\/product\/\">RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme<\/a>","recommended_dilution_buffer":"<a href=\"\/product\/\">InVivoPure pH 7.0 Dilution Buffer<\/a>","clone":"Nirsevimab","technical_data_sheet":"https:\/\/pneuma.bioxcell.com\/api\/v1\/products\/certificate-of-analysis\/SIM0088\/0\/0\/0?apikey=23D50188E6F74755AFFBF95BD41B140B","western_blot_image":null,"new_product_image":null,"product_references":null,"display_pubmed_logo":null,"modified":"2026-03-18 02:10:05","active":"Y"}

InVivoSIM anti-respiratory syncytial virus (RSV) F protein (Nirsevimab Biosimilar)

Clone	Catalog #	Category
Nirsevimab	SIM0088

USD 235 - USD 8140

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-respiratory syncytial virus (RSV) F protein (Nirsevimab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Nirsevimab, making it ideal for research use. Nirsevimab is a human IgG1 monoclonal antibody that targets the fusion (F) glycoprotein of respiratory syncytial virus (RSV), a highly contagious virus that causes serious respiratory infections, particularly in infants and older adults. The RSV F protein plays a critical role in viral entry by mediating the fusion of viral and host cell membranes, making it a key target for neutralization. Nirsevimab binds to a highly conserved epitope on the prefusion conformation of the RSV F protein, thereby preventing the conformational changes required for membrane fusion and subsequent infection. Unlike palivizumab, which binds both pre- and postfusion forms, Nirsevimab is specific to the prefusion form, enabling higher potency and prolonged protection. This Nirsevimab biosimilar is ideal for studying RSV entry mechanisms, neutralizing antibody responses, and RSV vaccine or therapeutic development.

InVivoSIM anti-respiratory syncytial virus (RSV) F protein (Nirsevimab Biosimilar) Specifications

Isotype	Human IgG1, κ
Recommended Isotype Control(s)	RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	RSV F protein
Reported Applications	In vivo functional assays in vitro functional assays Flow cytometry ELISA
Formulation	pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.