{"id":"522","post_author":null,"post_date":null,"post_date_gmt":null,"post_content":null,"post_title":"RecombiMAb anti-mouse 4-1BBL (CD137L)","post_excerpt":"The TKS-1-CP040 monoclonal antibody is a chimeric version of the original TKS-1 antibody. The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. The TKS-1-CP40 antibody contains no Fc mutations just as the original rat IgG2a antibody does not. The TKS-1-CP040 monoclonal antibody reacts with mouse 4-1BB ligand (4-1BBL), a type II transmembrane glycoprotein also known as CD137L. 4-1BBL is a 97 kDa member of the TNF superfamily and is expressed by dendritic cells, macrophages, and activated B and T lymphocytes. Interaction of 4-1BBL with 4-1BB (CD137) provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-\u03baB, c-Jun and p38 downstream pathways. The TKS-1 antibody has been shown to inhibit the binding of soluble 4-1BB to 4-1BBL in vitro.","post_status":"publish","comment_status":null,"ping_status":null,"post_password":null,"post_name":"recombimab-anti-mouse-4-1bbl-cd137l-cp040","to_ping":null,"pinged":null,"post_modified":null,"post_modified_gmt":null,"post_content_filtered":null,"post_parent":null,"guid":null,"menu_order":null,"post_type":null,"post_mime_type":null,"comment_count":null,"filter":null,"sku":"CP040","path":"\/product\/recombimab-anti-mouse-4-1bbl-cd137l-cp040\/","image":"https:\/\/pneuma.bioxcell.com\/Media\/Products\/bioxcell-cp040-recombimab-anti-mouse-4-1bbl-cd137l-tks-1-cp040.png","brand_id":null,"brand_name":null,"brand_slug":null,"brand_description":null,"isotype":"Mouse IgG2a,\u00a0\u03ba","immunogen":"Mouse 4-1BBL transfected NRK cells","reported_applications":"in vivo 4-1BBL blockade*\nELISA*\n*Reported for the original rat IgG2a TKS-1 antibody","aggregation":"<5%\nDetermined by SEC","formulation":"PBS, pH 7.0\nContains no stabilizers or preservatives","murine_pathogen_tests":"Mouse Norovirus: Negative\nMouse Parvovirus: Negative\nMouse Minute Virus: Negative\nMouse Hepatitis Virus: Negative\nReovirus Screen: Negative\nLymphocytic Choriomeningitis virus: Negative\nLactate Dehydrogenase-Elevating Virus: Negative\nMouse Rotavirus: Negative\nTheiler's Murine Encephalomyelitis: Negative\nEctromelia\/Mousepox Virus: Negative\nHantavirus: Negative\nPolyoma Virus: Negative\nMouse Adenovirus: Negative\nSendai Virus: Negative\nMycoplasma Pulmonis: Negative\nPneumonia Virus of Mice: Negative\nMouse Cytomegalovirus: Negative\nK Virus: Negative","human_pathogen_tests":"","toxicity_test_results":null,"endotoxin":"<ul><li>\u22640.5EU\/mg (\u22640.0005EU\/\u03bcg)<\/li><li>Determined by LAL gel clotting assay<\/li><\/ul>","purity":"<ul><li>\u226595%<\/li><li>Determined by SDS-PAGE<\/li><\/ul>","sterility":"0.2 \u03bcm filtration","production":"Purified from HEK293 cell supernatant in an animal-free facility","purification":"Protein G","composition":null,"volume":null,"concentration":null,"molecular_weight":"150 kDa","storage":"The antibody solution should be stored at the stock concentration at 4\u00b0C. Do not freeze.","rrid":"","recommended_isotype_control":"<a href=\"\/product\/\">InVivoPlus mouse IgG2a isotype control, unknown specificity<\/a>","recommended_dilution_buffer":"<a href=\"\/product\/\">InVivoPure pH 7.0 Dilution Buffer<\/a>","clone":"TKS-1-CP040","technical_data_sheet":"https:\/\/pneuma.bioxcell.com\/api\/v1\/products\/certificate-of-analysis\/CP040\/0\/0\/0?apikey=23D50188E6F74755AFFBF95BD41B140B","western_blot_image":null,"new_product_image":null,"product_references":null,"display_pubmed_logo":null,"modified":"2026-03-13 02:10:06","active":"Y"}

RecombiMAb anti-mouse 4-1BBL (CD137L)

Clone	Catalog #	Category
TKS-1-CP040	CP040

USD 541 - USD 7325

Technical Data Sheet

SDS Sheet

About RecombiMAb anti-mouse 4-1BBL (CD137L)

The TKS-1-CP040 monoclonal antibody is a chimeric version of the original TKS-1 antibody. The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. The TKS-1-CP40 antibody contains no Fc mutations just as the original rat IgG2a antibody does not. The TKS-1-CP040 monoclonal antibody reacts with mouse 4-1BB ligand (4-1BBL), a type II transmembrane glycoprotein also known as CD137L. 4-1BBL is a 97 kDa member of the TNF superfamily and is expressed by dendritic cells, macrophages, and activated B and T lymphocytes. Interaction of 4-1BBL with 4-1BB (CD137) provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways. The TKS-1 antibody has been shown to inhibit the binding of soluble 4-1BB to 4-1BBL in vitro.

RecombiMAb anti-mouse 4-1BBL (CD137L) Specifications

Isotype	Mouse IgG2a, κ
Recommended Isotype Control(s)	InVivoPlus mouse IgG2a isotype control, unknown specificity
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Mouse 4-1BBL transfected NRK cells
Reported Applications	in vivo 4-1BBL blockade* ELISA* *Reported for the original rat IgG2a TKS-1 antibody
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Production	Purified from HEK293 cell supernatant in an animal-free facility
Purification	Protein G
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.